I was on an internship and only had a crappy laptop with me when Overwatch came out, so I can say that it's definitely some degree of playable even with an HD 4500. I was at basically minimum settings and a significantly reduced resolution, but the framerate was consistent and the game is distinctive enough that blurry silhouettes are just about always good enough.
There are some online benchmarks available if you want more solid evidence. I've never used any of them, but they seem popular.
Also, Little Nightmares was claimed IRL.